Publications
19. Zhu, S., Bradfield, C., Mamiñska, A., Park, E.S., Kim, B.H., Kumar, P., Huang, S., Zhang, Y., Bewersdorf J., MacMicking, J.D. (2024) Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection. Science. 383(6686). DOI: 10.1126/science.abm9903. Article Link
18. Huang, S. (2023) Tuning the rheostat of immune gene translation. Stress Biology. 3, 7. https://doi.org/10.1007/s44154-023-00087-0. Article Link
17. Ao, K., Rohmann, PF., Huang, S., Li, L., Lipka, V., Chen, S., Wiermer, M., Li, X. (2023) Puncta‐localized TRAF domain protein TC1b contributes to the autoimmunity of snc1. The Plant Journal. 2023 Feb 17. Article Link
16. Kim, J.H., Castroverde, C.D.M., Huang, S., Li, C., Hilleary, R., Seroka, A., Sohrabi, R., Medina-Yerena, D., Huot, B., Want, J., Nomura, K., Marr, S.K., Wildermuth, M., Chen, T., MacMicking, J.D., He, SY. (2022) Increasing the resilience of plant immunity to a warming climate. Nature. 607: 339–344. https://doi.org/10.1038/ s41586-022-04902-y. Article Link
15. Huang, S., Zhu, S., Kumar, P., MacMicking, J.D. (2021) A phase-separated nuclear GBPL circuit controls immunity in plants. Nature. 594: 424–429. DOI: 10.1038/s41586-021-03572-6. Article Link
Highlights in Mol Plant (July 2021). DOI: 10.1016/j.molp.2021.07.022.
14. Gaudet, R., Zhu, S., Halder, A., Kim, B.H., Bradfield, C., Huang, S., Xu, D., Mamiñska, A., Nguyen, T. N., Lazarou, M., Karatekin, E., Gupta, K., MacMicking, J.D. (2021) A human apolipoprotein L with detergent-like activity kills intracellular pathogens. Science. 373(6552). DOI: 10.1126/science.abf8113. Article Link
13. Zhu, S., Bradfield, C., Mamiñska, A., Park, E.S., Kim, B.H., Kumar, P., Huang, S., Zhang, Y., Bewersdorf J., MacMicking, J.D. (2021) Cryo-ET of a human GBP coatomer governing cell-autonomous innate immunity to infection. bioRxiv. DOI: 10.1101/2021.08.26.457804. Article Link
12. Huang, S., Meng, Q., Mamiñska, A., MacMicking, J.D. (2019) Cell-autonomous immunity by IFN-induced GBPs in animals and plants. Current Opinion in Immunology. 60:71-80. DOI:10.1016/j.coi. 2019.04.017. (Review article) Article Link
11. Wang, L., Wen, R., Wang, J., Xiang, D., Wang, Q., Zang, Y., Wang, Z., Huang, S., Li, X., Datla, R., Fobert, P.R., Wang, H., Wei, Y., Xiao W. (2018) Arabidopsis UBC13 differentially regulates two programmed cell death pathways in responses to pathogen and low-temperature stress. New Phytologist. 221(2):919-934. DOI: 10.1111/nph.15435.
10. ╫Wu, Z., ╫Huang, S., ╫Zhang, X., Xia, S., Li, X. (2017) A GYF domain protein regulates plant NLR protein accumulation through translational repression. eLife. 6:e23684. DOI: 10.7554/eLife.23684. (╫Equal contribution) Article Link
9. Huang, S., Balgi, A., Pan, Y., Zhang, X., Du, L., Zhou, M., Roberge, M., Li, X. (2016) Identification of methylosome components as negative regulators of plant immunity using chemical genetics. Molecular Plant. 12(9), 1620–1633. DOI: 10.1016/j.molp.2016.10.006. Article Link
8. Huang, S., Chen, X., Zhong, X., Li, M., Ao, K., Huang, J., Li, X. (2016) Plant TRAF proteins regulate NLR immune receptor turnover. Cell Host & Microbe. 19(2), 204-215. DOI: 10.1016/j.chom.2016.01.005. Article Link
Highlights in Nature Plants (March 2016). DOI: 10.1038/nplants.2016.26.
7. Huang, S., Monaghan, J., Zhong, X., Lin, L., Sun, T., Dong, O.X., Li, X. (2014) HSP90s are required for NLR immune receptor accumulation in Arabidopsis. Plant Journal. 79(3), 427-439. DOI: 10.1111/tpj.12573. Article Link
6. Huang, Y., Minaker, S., Roth, C., Huang, S., Hieter, P., Lipka, V., Wiermer, M., Li, X. (2014) An E4 ligase facilitates polyubiquitination of plant immune receptor resistance proteins in Arabidopsis. Plant Cell. 26(1):485-496. DOI: 10.1105/tpc.113.119057. Article Link
5. Huang, Y., Chen, X., Liu, Y., Roth, C., Copeland, C., McFarlane, H.E., Huang, S., Lipka, V., Wiermer, M., Li, X. (2013) Mitochondrial AtPAM16 is required for plant survival and the negative regulation of plant immunity. Nature Communications. 4, 2558. DOI: 10.1038/ncomms3558. Article Link
4. Xia, S., Cheng, Y.T., Huang, S., Win, J., Soards, A., Jinn, T.L., Jones, J.D., Kamoun, S., Chen, S., Zhang, Y., Li, X. (2013) Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation. Plant Physiology. 162(3):1694-705. DOI: 10.1104/pp.113.214551. Article Link
3. Cheng, Y.T., Li, Y., Huang, S., Huang, Y., Dong, X., Zhang, Y., Li, X. (2011) Stability of plant immune-receptor resistance proteins is controlled by SKP1-CULLIN1-F-box (SCF)-mediated protein degradation. Proc. Natl. Acad. Sci. USA. 108(35):14694-9. DOI: 10.1073/pnas.1105685108. Article Link
2. Woloshen, V., Huang, S., Li, X. (2011) RNA-binding proteins in plant immunity. Journal of Pathogens. DOI: 10.4061/2011/278697.
1. Germain, H., Qu, N., Cheng, Y.T., Lee, E., Huang, Y., Dong, O.X., Gannon, P., Huang, S., Ding, P., Li, Y., Sack, F., Zhang, Y., Li, X. (2010) MOS11: a new component in the mRNA export pathway. PLoS Genetics. 6, e1001250. DOI: 10.1371/journal.pgen.1001250.